PAMAM Dendrimers as Quantized Building Blocks for Novel Nanostructures.

A Novel Nanofiltration Membrane Prepared with PAMAM and Graphene oxide for Desalination

Nanofiltration is increasingly gaining attention in many separation and treatment processes such as water softening, color removal and separation of medicines. Nanofiltration membranes are often negatively charged, displaying separation characteristics in the intermediate range between reverse osmosis and ultrafiltration. In this research, a novel nanofiltration membrane prepared with poly(amid...

Partitioning of poly(amidoamine) dendrimers between n-octanol and water.

Dendritic nanomaterials are emerging as key building blocks for a variety of nanoscale materials and technologies. Poly(amidoamine) (PAMAM) dendrimers were the first class of dendritic nanomaterials to be commercialized. Despite numerous investigations, the environmental fate, transport, and toxicity of PAMAM dendrimers is still not well understood. As a first step toward the characterization o...

Cellular Delivery of Nanostructured Poly(amido amine) Dendrimers and Establishment of a Simple Methodology upon Ninhydrin Reaction

      Dendrimer based nanostructures have been increasingly used for delivery of drugs/genes. These nanosystems, as non-viral gene delivery systems, were shown to have relatively high transfection efficiency despite exerting somewhat cytotoxicity. In this current investigation, poly(amido amine) (PAMAM) dendrimers, generation  (G) zero to five, PEGylated PAMAM G3 and a new quaternized PAMAM G4 ...

Selective cytotoxicity of PAMAM G5 core–PAMAM G2.5 shell tecto-dendrimers on melanoma cells

BACKGROUND The controlled introduction of covalent linkages between dendrimer building blocks leads to polymers of higher architectural order known as tecto-dendrimers. Because of the few simple steps involved in their synthesis, tecto-dendrimers could expand the portfolio of structures beyond commercial dendrimers, due to the absence of synthetic drawbacks (large number of reaction steps, exce...

Birth of a New Macromolecular Architecture: Dendrimers as Quantized Building Blocks for Nanoscale Synthetic Organic Chemistry